Endocrine Abstracts

Introduction: Although alpha-glucosidase inhibitors (aGIs), including acarbose, are recommended in several international guidelines, they are not widely used worldwide due to a perception that they are less effective in Caucasians than Asians. A study was undertaken to investigate whether differences between ethnicity/region populations exist.Methods/design: We pooled data from 10 non-interventional and post-marketing studies from 21 countries, provinces...

Background: Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in congenital adrenal hyperplasia (CAH).Objective: To investigate the frequency of adrenal abnormalities and TART in an unselected adult population of CAH due to 21-hydroxylase deficiency (21-OH) and whether adrenal and testicular pathology correlate with disease categories, current hormone levels and treatment.Patient...

Introduction: Medullary and papillary thyroid carcinoma (MTC and PTC) are two types of thyroid cancer that can originate from activating mutations or rearrangements in the RET gene. Therapeutic options are limited in recurrent disease but since RET is a tyrosine kinase (TK) receptor involved in cellular growth and proliferation, treatment with a TK-inhibitor might be promising. Several TK-inhibitors have been tested in clinical trials, but it is unknown which inhibitor is most...